911771

Lenalidomide-Photoswitch1-NH₂ hydrochloride

≥95%

• 同義詞: (E)-N-(4-Aminobutyl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)diazenyl)-2,6-dimethoxyphenoxy)acetamide hydrochloride, PHOTAC template, Photoswitchable protein degrader building block for PROTAC^® research
• 經驗公式（希爾表示法）: C₂₇H₃₂N₆O₇ · xHCl
• CAS號碼: 2363156-76-5
• 分子量：: 552.58 (free base basis)
• MDL號碼: MFCD34674289
• 分類程式碼代碼: 12352101

屬性

• ligand: lenalidomide
• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder or crystals
• 反應適用性: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• 存貨情形: available only in USA
• 官能基: amine
• 儲存溫度: 2-8°C
• SMILES 字串: NCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C4C(NC(CC4)=O)=O)C3=O)C=C1OC)=O.Cl
• InChI: 1S/C27H32N6O7.ClH/c1-38-21-12-16(13-22(39-2)25(21)40-15-24(35)29-11-4-3-10-28)31-32-19-7-5-6-17-18(19)14-33(27(17)37)20-8-9-23(34)30-26(20)36;/h5-7,12-13,20H,3-4,8-11,14-15,28H2,1-2H3,(H,29,35)(H,30,34,36);1H/b32-31+;
• InChI 密鑰: BEBAPHRSEIHKIQ-MRRLHAJBSA-N

描述

應用

Learn more: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC^® Degraders for Targeted Protein DegradationProtein degrader building block Lenalidomide-Photoswitch1-NH₂ hydrochloride enables the synthesis of PHOtochemically TArgeting Chimeras (PHOTACs), or photoswitchable proteolysis-targeting chimeras (PROTACs) that can be reversibly activated with different wavelengths of light. Developed in the Trauner and Pagano labs, PHOTACs are inactive in the dark but are activated to the cis isomer via irradiation at 390 nm and reversibly deactivated at wavelengths >450 nm. As described in Reynders, et al, this conjugate was used to prepare PHOTAC-I-3 and contains a Cereblon (CRBN)-recruiting ligand, an azobenzene photoswitchable crosslinker, and pendant amine for reactivity with an acid on the target warhead. Light-mediated control of the resulting PHOTAC affords advanced temporal and spatial control of targeted protein degradation.

Suggested wavelengths for photoswitching:

• Switch to cis isomer: 390 nm (380-400 nm)
• Switch to trans isomer (thermally more stable isomer): >450 nm
  Low-intensity light needed for photoactivation is not cytotoxic.

Browse our full offering of degrader building blocks that streamlines the synthesis of degrader libraries.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Learn more:

• Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
• Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

其他說明

1. PHOTACs enable optical control of protein degradation

2. PhotoPROTACs: A Novel Biotechnology for Cancer Treatment

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable