923907
6F,C5-Pomalidomide-piperazine-piperidine-4-carbothioamide hydrochloride
同義詞:
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(piperidine-4-carbonothioyl)piperazin-1-yl)isoindoline-1,3-dione hydrochloride, Crosslinker–E3 ligase ligand conjugate, Protein degrader building block
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About This Item
經驗公式（希爾表示法）:
C23H26FN5O4S · xHCl
分子量：:
487.55 (free base basis)
分類程式碼代碼:
12352101
NACRES:
NA.21
推薦產品
ligand
6F,C5-Pomalidomide
品質等級
反應適用性
reactivity: carboxyl reactive
reagent type: ligand-linker conjugate
官能基
amine
儲存溫度
2-8°C
SMILES 字串
O=C1C(N2C(C(C=C(F)C(N3CCN(C(C4CCNCC4)=S)CC3)=C5)=C5C2=O)=O)CCC(N1)=O.Cl
應用
Protein degrader building block 6F,C5-Pomalidomide-piperazine-piperidine-4-carbothioamide hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
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Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
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其他說明
法律資訊
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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產品號碼
描述
訂價
訊號詞
Danger
危險聲明
危險分類
Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Daniel P Bondeson et al.
Annual review of pharmacology and toxicology, 57, 107-123 (2016-10-13)
Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of
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