910074

27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid

≥95%

• Synonim(y): 2-2-2-2-2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₆-acid
• Wzór empiryczny (zapis Hilla): C₂₃H₄₄O₁₀
• Masa cząsteczkowa: 480.59
• Kod UNSPSC: 12352106

Właściwości

• Próba: ≥95%
• Postać: liquid
• przydatność reakcji: reagent type: linker
• grupa funkcyjna: carboxylic acid; ester
• temp. przechowywania: 2-8°C
• ciąg SMILES: O=C(CCCCCCOCCOCCOCCOCCOCCOCC(O)=O)OC(C)(C)C

Opis

Zastosowanie

This heterobifunctional, PEGylated crosslinker 27,27-dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or pproteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

Inne uwagi

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable