910058

2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid

≥95%

• Synonim(y): 2-2-6 PROTAC^® linker, Alkyne-PEG₂-acid, Bifunctional linker
• Wzór empiryczny (zapis Hilla): C₁₂H₂₀O₄
• Masa cząsteczkowa: 228.28
• Kod UNSPSC: 12352106

Właściwości

• Próba: ≥95%
• Postać: (Viscous Liquid or Semi-solid or Paste or Solid)
• przydatność reakcji: reaction type: click chemistry; reagent type: linker
• grupa funkcyjna: alkyne; carboxylic acid
• temp. przechowywania: 2-8°C
• ciąg SMILES: OC(COCCOCCCCCCC#C)=O

Opis

Zastosowanie

This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₂-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

Inne uwagi

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable