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NOS1

nitric oxide synthase 1 (neuronal)

Synonimy:
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(4842) Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
  • Mouse(18125) nitric oxide synthase 1, neuronal
  • Rat(24598) nitric oxide synthase 1, neuronal
  • Zebrafish(60658) nitric oxide synthase 1 (neuronal)
  • domestic cat(101100342) nitric oxide synthase 1 (neuronal)
  • cow(536132) nitric oxide synthase 1 (neuronal)
  • Horse(100051079) nitric oxide synthase 1 (neuronal)
  • dog(477498) nitric oxide synthase 1 (neuronal)
  • chicken(427721) nitric oxide synthase 1 (neuronal)
  • naked mole-rat(101711993) nitric oxide synthase 1 (neuronal)
  • Domestic Rabbit(100009243) nitric oxide synthase 1 (neuronal)
  • domestic guinea pig(100729682) nitric oxide synthase 1 (neuronal)

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Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
(+)-Thalidomide, ≥98% (HPLC), powder,
Gatunek
human, mouse, rat
(−)-Thalidomide, >98%, solid,
Gatunek
human, mouse, rat
Ammonium pyrrolidinedithiocarbamate, ~99%,
Gatunek
human
Melatonin, powder, ≥98% (TLC),
Gatunek
human
(±)-Thalidomide, ≥98%, powder,
Gatunek
human, mouse, rat

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-phospho-n-NOS (pSer852) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-NOS1 (Ab-852) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunofluorescence
Anti-Nitrotyrosine Mouse mAb (CC22.8C7.3), liquid, clone CC22.8C7.3, Calbiochem®,
Reaktywność gatunkowa
all
Zastosowanie
Anti-Nitrotyrosine Magnetic Bead Conjugate Antibody, from rabbit,
Reaktywność gatunkowa
all
Zastosowanie
immunoprecipitation (IP)
Anti-Nitrotyrosine Antibody, clone 1A6, Alexa Fluor 555 conjugate, clone 1A6, Upstate®, from mouse,
Reaktywność gatunkowa
vertebrates
Zastosowanie
flow cytometry
western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
5-Methyl-2-nitroaniline, 95%,
Gatunek
rat
4-Nitrocatechol, ≥96.0%,
Gatunek
rat
Spermidine trihydrochloride, ≥98% (TLC),
Gatunek
human
7,7,8,8-Tetracyanoquinodimethane, 98%,
Gatunek
rat, human
2-Amino-4,6-dimethylpyridine, 99%,
Gatunek
human

Kits

Numer produktu
Opis
Gatunek
Nitric Oxide Synthase Detection System, Fluorimetric, sufficient for 200 reactions,
Gatunek
human

Small Molecule - Precursor

Numer produktu
Opis
Gatunek
L-Arginine, ,
Gatunek
rat, human
L-Arginine, BioUltra, ≥99.5% (NT),
Gatunek
rat, human
L-Arginine, 99%, FCC, FG,
Gatunek
rat, human
L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%,
Gatunek
rat, human
L-Arginine, reagent grade, ≥98%,
Gatunek
rat, human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting mouse Nos1,
Gatunek
mouse