PHR1188

13-cis-レチノイン酸

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: イソトレチノイン
• 実験式（ヒル表記法）: C₂₀H₂₈O₂
• CAS番号: 4759-48-2
• 分子量: 300.44
• EC Number: 225-296-0
• MDL番号: MFCD00079542
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823198
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. I0800000; traceable to USP 1353500
• APIファミリー: isotretinoin
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• mp: 172-175 °C (lit.)
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: -10 to -25°C
• SMILES記法: [H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
• InChI Key: SHGAZHPCJJPHSC-XFYACQKRSA-N
• 遺伝子情報: human ... RARA(5914) , RARB(5915) , RARG(5916)

詳細

詳細

Isotretinoin is a vitamin A derivative, obtained from the isomerization of retinoic acid in the body. It is therapeutically used to treat severe recalcitrant nodular acne. It is also reported to exhibit anti-inflammatory and anti-tumor activities.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Isotretinoin may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

13-cis-レチノイン酸 (RA)は抗炎症作用および抗腫瘍作用を示します。RAの作用は、RAR-βおよびRAR-α受容体を介します。 RAは、サイトカイン刺激したマウスメサンギウム細胞において、iNOS発現および活性を減弱します。膨潤および膜電位の低下として観察されるミトコンドリア膜透過性遷移を誘導し、チトクロムcの遊離を促進することから、アポト-シス経路を介したメカニズムであることが示されます。これらの活性は、EGTAおよびシクロスポリンAによって逆転します。また、RAは転写の増加を介してMMP-1タンパク質発現を部分的に亢進します。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC0144 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H315,H319,H335,H360FD
• 注意書き: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable