PHR1187

レチノイン酸

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: ATRA, オールtransレチノイン酸, トレチノイン, ビタミンA酸
• 実験式（ヒル表記法）: C₂₀H₂₈O₂
• CAS番号: 302-79-4
• 分子量: 300.44
• Beilstein: 2057223
• EC Number: 206-129-0
• MDL番号: MFCD00001551
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823197
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. T1850000; traceable to USP 1674004
• APIファミリー: tretinoin
• フォーム: solid
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• mp: 180-181 °C (lit.)
• アプリケーション: food and beverages
• フォーマット: neat
• 保管温度: -10 to -25°C
• SMILES記法: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• InChI Key: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• 遺伝子情報: human ... RARA(5914) , RARB(5915) , RARG(5916)

詳細

詳細

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tretinoin is a medication used for the treatment of severe cystic acne. The drug acts by regulating epithelial cell growth and differentiation, sebum production, collagen synthesis and keratinization of the skin.

アプリケーション

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Tretinoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

生物化学的／生理学的作用

all−transレチノイン酸 (ATRA)は、レチノイン酸受容体(RAR)とレチノイドX受容体(RXR)の両方のリガンドです。結合したRARおよびRXRは、正常細胞と腫瘍細胞の増殖や分化を制御する転写因子として機能します。チトクロムP450(CYP)は、ATRAの4-ヒドロキシル化を触媒します。レチノイン酸は、胚性幹細胞がニュ-ロンになるのを促進します。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAB7354 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS08,GHS07,GHS09
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H360FD,H410
• 注意書き: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable