PHR1141

オンダンセトロン ヒドロクロリド

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: オンダンセトロン 塩酸塩 二水和物, 1,2,3,9-テトラヒドロ-9-メチル-3-[(2-メチル-1H-イミダゾール-1-イル)メチル]-4H-カルバゾール-4-オン 塩酸塩, GR 38032F
• 実験式（ヒル表記法）: C₁₈H₁₉N₃O · HCl · 2H₂O
• CAS番号: 103639-04-9
• 分子量: 365.85
• MDL番号: MFCD00374371
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823161
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP; traceable to Ph. Eur. Y0000218; traceable to USP 1478582
• APIファミリー: ondansetron
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C
• InChI: 1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2
• InChI Key: VRSLTNZJOUZKLX-UHFFFAOYSA-N
• 遺伝子情報: human ... HTR3A(3359)

詳細

詳細

Ondansetron Hydrochloride acts as a 5HT3 (serotonin) antagonist and is a powerful antiemetic drug. It is widely used for the prevention and treatment of nausea and vomiting related to post-operative states, cancer chemotherapy and radiotherapy, and chronic medical illness. It has been found to exhibit inconsistent bioavailability resulting from its poor aqueous solubility and high first-pass hepatic metabolism.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Ondansetron Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by spectrophotometric, electrochemical, and chromatographic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

5-HT₃ セロトニン受容体拮抗薬

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA7141 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS06,GHS05,GHS09
• シグナルワード: Danger
• 危険有害性情報: H301,H318,H410
• 注意書き: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P391
• 危険有害性の分類: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable