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Merck

ADORA2A

adenosine A2a receptor

別名:
A2aR, ADORA2, RDC8
Species:
UniProtKB ID:
遺伝子ID:
  • Human(135) Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
  • Mouse(11540) adenosine A2a receptor
  • Rat(25369) adenosine A2a receptor
  • sheep(101112926) adenosine A2a receptor
  • naked mole-rat(101718082) adenosine A2a receptor
  • domestic guinea pig(100135473) adenosine A2a receptor
  • chicken(427705) adenosine A2a receptor
  • dog(403960) adenosine A2a receptor
  • cow(617828) adenosine A2a receptor
  • Horse(100034039) adenosine A2a receptor
  • domestic cat(101080742) adenosine A2a receptor

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Small Molecule - Agonist

製品番号
詳細
Species
CGS-21680 塩酸塩 水和物, solid,
Species
human
アデノシン, ,
Species
human
ホルマイシンA, from Streptomyces kaniharaensis, ≥98% (HPLC),
Species
human
アデノシン, United States Pharmacopeia (USP) Reference Standard,
Species
human
アデノシン, phyproof® Reference Substance,
Species
human

Small Molecule - Antagonist

製品番号
詳細
Species
イストラデフィリン, ≥98% (HPLC),
Species
human
3-イソブチル-1-メチルキサンチン, ≥99%, BioUltra,
Species
rat
ヘマトキシリン, ,
Species
rat
3-メチルキサンチン, 98%,
Species
rat
ヘマトキシリン, certified by the Biological Stain Commission,
Species
rat

Antibodies

製品番号
詳細
交差性
アプリケーション
抗アデノシン受容体A2A抗体、クローン7F6-G5-A2, clone 7F6-G5-A2, Upstate®, from mouse,
交差性
canine, dog, human, mouse, rabbit, rat
アプリケーション
flow cytometry
immunohistochemistry

western blot
Anti-ADORA2A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
flow cytometry
western blot
Anti-Adenosine A2a Receptor Antibody, Chemicon®, from rabbit,
交差性
bovine, canine, human, pig
アプリケーション
ELISA
immunocytochemistry

immunohistochemistry

western blot
Anti-A2A Adenosine Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
交差性
canine, human
アプリケーション
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Adenosine A2a Receptor Antibody, serum, Chemicon®,
交差性
bovine, canine, human, pig, rat
アプリケーション
ELISA
western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
EHNA 塩酸塩, ≥98% (HPLC),
Species
human
ジラゼプ 二塩酸塩, powder,
Species
human
8-(3-クロロスチリル)カフェイン, ≥98% (HPLC), solid,
Species
human, rat, mouse
5′-デオキシ-5′-(メチルチオ)アデノシン, ,
Species
human, rat, mouse
α-ナフトフラボン, ≥98%,
Species
human, rat

Small Molecule - Ligand

製品番号
詳細
Species
2-クロロ-2′-デオキシアデノシン, antileukemic,
Species
rat, human
1,7-ジメチルキサンチン, ~98%, solid,
Species
rat, human
クロロ-IB-MECA, solid, ≥98% (HPLC),
Species
human, rat
アデノシン, ≥99%,
Species
human, rat
テオフィリン, anhydrous, ≥99%, powder,
Species
mouse, human, rat

Small Molecule - Mixed Agonist/Antagonist

製品番号
詳細
Species
2-Iodoadenosine, 97%,
Species
human, rat
2-フルオロアデニン-9-β-D-アラビノフラノシド, DNA synthesis and methylation inhibitor,
Species
rat, human
2-フルオロアデノシン, 97%,
Species
rat, human
2-クロロアデノシン, ,
Species
human, rat
クロロ-IB-MECA, solid, ≥98% (HPLC),
Species
human, rat

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting mouse Adora2a,
Species
mouse
MISSION® esiRNA, targeting human ADORA2A, SPECC1L-ADORA2A,
Species
human