SMB00287

ホルマイシンA

from Streptomyces kaniharaensis, ≥98% (HPLC)

• 別名: 7-アミノ-3-(β-D-リボフラノシル)-1H-ピラゾロ[4,3-d]ピリミジン
• 実験式（ヒル表記法）: C₁₀H₁₃N₅O₄
• CAS番号: 6742-12-7
• 分子量: 267.24
• Beilstein: 624229
• MDL番号: MFCD00036807
• UNSPSCコード: 51102829
• PubChem Substance ID: 329824924
• NACRES: NA.85

特性

• 由来生物: Streptomyces kaniharaensis
• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: (Keep container tightly closed in a dry and well-ventilated place.)
• 色: white to off-white
• 溶解性: DMSO: soluble 1 mg/mL; H₂O: soluble 3 mg/mL
• 抗生物質活性スペクトル: viruses (Antiretroviral)
• 作用機序: enzyme | inhibits
• 保管温度: −20°C
• SMILES記法: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI Key: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• 遺伝子情報: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

詳細

詳細

Chemical structure: nucleoside

Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase.

生物化学的／生理学的作用

Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription.

Formycin A possess antitumor function, along with its antibacterial and antiviral activity.

包装

10MG

その他情報

Keep container tightly closed in a dry and well-ventilated place.

Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable