01890

アデノシン

• 別名: 9-β-D-リボフラノシルアデニン, アデニン-9-β-D-リボフラノシド, アデニンリボシド
• 実験式（ヒル表記法）: C₁₀H₁₃N₅O₄
• CAS番号: 58-61-7
• 分子量: 267.24
• Beilstein: 93029
• EC Number: 200-389-9
• MDL番号: MFCD00005752
• UNSPSCコード: 12352200
• eCl@ss: 32160413
• PubChem Substance ID: 329747369
• NACRES: NA.77

特性

• 形状: powder
• 品質水準: 200
• 光学活性: [α]20/D −70±3°, c = 2% in 5% NaOH
• 強熱残分: ≤0.1% (as SO₄)
• mp: 234-236 °C (lit.)
• 微量陽イオン: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; Mg: ≤20 mg/kg; Mn: ≤5 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• 保管温度: 2-8°C
• SMILES記法: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI Key: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• 遺伝子情報: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

詳細

詳細

Adenosine is a purine nucleoside base. It consists of adenine bound to a ribose sugar molecule via a glycosidic bond. Adenosine is found intracellularly and extracellularly in living cells. It acts as a precursor and as a metabolite of adenine nucleotides. In all living organisms, adenosine acts as an essential structural factor for adenosinetriphosphate (ATP), adenosine diphosphate (ADP), and cyclic adenosine monophosphate (cAMP), thereby playing an important role in energy transfer. Adenosine plays a crucial role in the central nervous system, endocrine system, inflammatory and immune response, and cardiovascular system. It is an important endogenous modulator of kidney function, lung function, pain, and sleep via the activation of adenosine receptors.

アプリケーション

Adenosine has been used as a standard to determine the adenosine content in whole heart samples from mice.

生物化学的／生理学的作用

アデノシン受容体に作用する内因性神経伝達物質です。心臓保護作用はA₁アデノシン受容体の活性化に関連するものと考えられます。アデノシンの抗血小板作用および抗炎症作用は、A₂アデノシン受容体を介して起こると思われます。対照的に、アデノシンは、喘息や慢性閉塞性肺疾患(COPD)の炎症誘発性メディエ-タとも考えられています。

その他情報

Substrate for the assay of adenosine deaminase

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)