D5294

ジラゼプ 二塩酸塩

powder

• 別名: ASTA C 4898, N,N′-ビス(3-[3,4,5-トリメトキシベンゾイルオキシ]プロピル)ホモピペラジン 二塩酸塩, コルメリアン
• 実験式（ヒル表記法）: C₃₁H₄₄N₂O₁₀ · 2HCl
• CAS番号: 20153-98-4
• 分子量: 677.61
• EC Number: 243-548-8
• MDL番号: MFCD00133267
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278372
• NACRES: NA.77

特性

• 形状: powder
• 品質水準: 200
• 色: white
• 溶解性: H₂O: 10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: Cl[H].Cl[H].COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2
• InChI: 1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H
• InChI Key: VILIWRRWAWKXRW-UHFFFAOYSA-N
• 遺伝子情報: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

詳細

詳細

Dilazep comprises central cyclic diamine and phenyl rings connected via alkyl linkers.

アプリケーション

Dilazep dihydrochloride has been used in estrogen receptor (ERα) antagonistic assay. It has also been used as an equilibrative nucleoside transporter inhibitor (ENT 1 and 2) in cancer cell lines.

生物化学的／生理学的作用

Dilazep is a equilibrative nucleoside transporter 1 (ENTs) inhibitor. It is an antianginal drug and an effective coronary vasodilator. Dilazep elicits anti-albuminuric effects and is an anti-platelet agent. It is a potent adenosine uptake inhibitor and suppresses effects of ischemia.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves