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Key Documents

T2879

Sigma-Aldrich

Tyramine hydrochloride

≥98% (TLC), powder, neuromodulator

Sinonimo/i:

4-(2-Aminoethyl)phenol hydrochloride, 4-Hydroxyphenethylamine hydrochloride, Tyrosamine hydrochloride

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About This Item

Formula condensata:
HOC6H4CH2CH2NH2 · HCl
Numero CAS:
Peso molecolare:
173.64
Beilstein:
3627058
Numero CE:
Numero MDL:
Codice UNSPSC:
12352116
ID PubChem:
NACRES:
NA.77

product name

Tyramine hydrochloride, ≥98%

Livello qualitativo

Saggio

≥98%

Punto di fusione

271-274 °C (lit.)

Solubilità

H2O: soluble 50 mg/ml, clear, colorless to faintly yellow

Stringa SMILE

Cl[H].NCCc1ccc(O)cc1

InChI

1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H
RNISDHSYKZAWOK-UHFFFAOYSA-N

Informazioni sul gene

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Applicazioni

Tyramine hydrochloride has been:
  • coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure
  • labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis
  • used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification

Azioni biochim/fisiol

Tyramine is a biogenic amine and a neuromodulator localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders. Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.
Can enter catecholaminergic terminals and be released as a false transmitter.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Certificati d'analisi (COA)

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Immunostaining Enhancement
Immunohistochemistry: Basics and Methods, 47-59 (2009)
Two functional but noncomplementing Drosophila tyrosine decarboxylase genes distinct roles for neural tyramine and octopamine in female fertility
Cole Shannon H, et al.
Test, 280(15), 14948-14955 (2005)
Urocortin and corticotropin-releasing factor receptor 2 in human renal cell carcinoma: disruption of an endogenous inhibitor of angiogenesis and proliferation
Tezval Hossein, et al.
World Journal of Urology, 27(6), 825-825 (2009)
A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster
Nagaya Y, et al.
Neuroscience Letters, 329(3), 324-328 (2002)
Pia Thaning et al.
Diabetes care, 34(5), 1186-1191 (2011-03-31)
Sympathetic vasoconstriction is blunted in contracting human skeletal muscles (functional sympatholysis). In young subjects, infusion of adenosine and ATP increases blood flow, and the latter compound also attenuates α-adrenergic vasoconstriction. In patients with type 2 diabetes and age-matched healthy subjects

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