H7125

Histamine

≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist

• Sinonimo/i: 2-(4-Imidazolyl)ethylamine
• Formula empirica (notazione di Hill): C₅H₉N₃
• Numero CAS: 51-45-6
• Peso molecolare: 111.15
• Beilstein: 2012
• Numero CE: 200-100-6
• Numero MDL: MFCD00005210
• Codice UNSPSC: 12352116
• eCl@ss: 32160406
• ID PubChem: 24895783
• NACRES: NA.77

Proprietà

• product name: Histamine, ≥97.0%
• Livello qualitativo: 200
• Saggio: ≥97.0%
• P. eboll.: 167 °C/0.8 mmHg (lit.)
• Punto di fusione: 83-84 °C (lit.)
• Temperatura di conservazione: −20°C
• Stringa SMILE: NCCc1c[nH]cn1
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8); NTYJJOPFIAHURM-UHFFFAOYSA-N
• Informazioni sul gene: human ... CA1(759) , CA2(760) , HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340) ; rat ... Hrh1(24448) , Hrh3(85268)

Descrizione

Descrizione generale

Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.

Applicazioni

Histamine has been used:

• to stimulate regulated cellular secretion
• in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
• to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium

Azioni biochim/fisiol

Endogenous H₁ and H₂ histamine receptor agonist; H₁ activation mobilizes Ca²⁺; H₂ activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.

Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H315,H317,H319,H334,H335
• Consigli di prudenza: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves