53300

Histamine dihydrochloride

≥99.0% (AT), powder or crystals, endogenous histamine receptor agonist

• Sinonimo/i: 2-(4-Imidazolyl)ethylamine dihydrochloride
• Formula empirica (notazione di Hill): C₅H₉N₃ · 2HCl
• Numero CAS: 56-92-8
• Peso molecolare: 184.07
• Beilstein: 3624116
• Numero CE: 200-298-4
• Numero MDL: MFCD00012703
• Codice UNSPSC: 12352116
• eCl@ss: 32160406
• ID PubChem: 329757931
• NACRES: NA.77

Proprietà

• product name: Histamine dihydrochloride, ≥99.0% (AT)
• Saggio: ≥99.0% (AT)
• Forma fisica: powder or crystals
• Residuo alla calcinazione: ≤0.2%
• Perdita: ≤0.2% loss on drying, 20 °C (HV)
• Punto di fusione: 244-247 °C; 249-252 °C (lit.)
• Solubilità: H₂O: 0.1 g/mL, clear, colorless
• Anioni in tracce: sulfate (SO₄^2-): ≤200 ppm
• Cationi in tracce: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• Stringa SMILE: Cl[H].Cl[H].NCCc1c[nH]cn1
• InChI: 1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H; PPZMYIBUHIPZOS-UHFFFAOYSA-N
• Informazioni sul gene: human ... HRH1(3269)

Descrizione

Descrizione generale

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.

Azioni biochim/fisiol

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H₂ histamine receptor.

Altre note

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H317,H319,H334,H335
• Consigli di prudenza: P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves