H7250

Histamine dihydrochloride

≥99% (TLC), powder, endogenous histamine receptor agonist

• Sinonimo/i: 2-(4-Imidazolyl)ethylamine dihydrochloride
• Formula empirica (notazione di Hill): C₅H₉N₃ · 2HCl
• Numero CAS: 56-92-8
• Peso molecolare: 184.07
• Beilstein: 3624116
• Numero CE: 200-298-4
• Numero MDL: MFCD00012703
• Codice UNSPSC: 12352116
• eCl@ss: 32160406
• ID PubChem: 24277777
• NACRES: NA.77

Proprietà

• Nome del prodotto: Histamine dihydrochloride, ≥99% (TLC), powder
• Saggio: ≥99% (TLC)
• Stato: powder
• Colore: white to off-white
• Punto di fusione: 249-252 °C (lit.)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl[H].Cl[H].NCCc1c[nH]cn1
• InChI: 1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H; PPZMYIBUHIPZOS-UHFFFAOYSA-N
• Informazioni sul gene: human ... HRH1(3269) , HRH2(3274)

Descrizione

Descrizione generale

Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.

Applicazioni

Histamine dihydrochloride has been used:

• as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
• to determine its level in fish using HPLC (high performance liquid chromatography)
• to assess the tracheal response to antigens in guinea-pigs

Azioni biochim/fisiol

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H317,H319,H334,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves