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Key Documents

1021204

USP

4-Aminophenol

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

4-Hydroxyaniline

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About This Item

Fórmula linear:
H2NC6H4OH
Número CAS:
Peso molecular:
109.13
Beilstein:
385836
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

paracetamol, acetaminophen, mesalazine

fabricante/nome comercial

USP

pf

185-189 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

Nc1ccc(O)cc1

InChI

1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2

chave InChI

PLIKAWJENQZMHA-UHFFFAOYSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.4-Aminophenol is the principal degradation product of acetaminophen, formed as an impurity during its hydrolysis.

Aplicação

This USP reference standard is intended for use in specified quality tests and assays.
Also used to prepare standard and system suitability solutions to test for the presence of 4-aminophenol as an impurity in various pharmaceutical dosage forms of acetaminophen, according to the United States Pharmacopeia (USP) monographs:
  • Mesalamine
  • Acetaminophen Tablets
  • Acetaminophen Oral Suspension
  • Tramadol Hydrochloride and Acetaminophen Tablets

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

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Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2

Órgãos-alvo

Kidney

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Mesalamine
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(6), 2800-2800 (2020)
Acetaminophen Oral Suspension
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(6), 42-42 (2021)
Acetaminophen tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(3), 45-45 (2021)
Soumabha Bag et al.
Analytica chimica acta, 860, 37-42 (2015-02-16)
Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization. Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested
Chongming Liu et al.
Journal of mass spectrometry : JMS, 49(8), 692-699 (2014-07-22)
On contrary to the widely accepted conviction that the m/z 93 ion derived from phenol does not react with CO2, we demonstrate that it makes an adduct with CO2 to a small but demonstrable extent. For example, the product-ion mass

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