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1003009

USP

Acetaminofeno

Name: Acetaminofeno
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

4′-Hidroxiacetanilida, 4-Acetamidofenol, N-(4-Hidroxifenil)acetamida, N-Acetil-4-aminofenol, APAP, Paracetamol

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About This Item

Fórmula linear:

CH₃CONHC₆H₄OH

Número CAS:

103-90-2

Peso molecular:

151.16

Beilstein:

2208089

Número MDL:

MFCD00002328

Código UNSPSC:

41116107

ID de substância PubChem:

329748124

NACRES:

NA.24

grau

pharmaceutical primary standard

família API

acetaminophen, paracetamol

fabricante/nome comercial

USP

pf

168-172 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

chave InChI

RZVAJINKPMORJF-UHFFFAOYSA-N

Informações sobre genes

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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Categorias relacionadas

Analytical Reference Materials for the Pharma Industry

Pharmacopeia & Metrological Institute Standards

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Acetaminophen USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

Acetaminophen Tablets
Acetaminophen Capsules
Acetaminophen Suppositories
Acetaminophen Oral Suspension
Acetaminophen Oral Solution
Acetaminophen and Caffeine Tablets
Acetaminophen Extended-Release Tablets

Analgésico.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Outras notas

Sales restrictions may apply.

produto relacionado

Nº do produto

Descrição

Preços

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

364.3 °F - Pensky-Martens closed cup

Ponto de fulgor (°C)

184.6 °C - Pensky-Martens closed cup

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Acetaminophen

USP43-NF38: United States Pharmacopeia and National Formulary

United States Pharmacopeia, 39(6), 38-38 (2020)

Acetaminophen tablets

USP43-NF38: United States Pharmacopeia and National Formulary

United States Pharmacopeia, 43(3), 45-45 (2021)

Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.

Mitchell R McGill et al.

Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.

The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.

Garry G Graham et al.

Inflammopharmacology, 21(3), 201-232 (2013-05-31)

Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective

Paracetamol to induce ductus arteriosus closure: is it valid?

Karel Allegaert et al.

Archives of disease in childhood, 98(6), 462-466 (2013-04-23)

There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure

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