Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

View All Documentation

SML0440

Sigma-Aldrich

Spautin-1

≥98% (HPLC)

Sinônimo(s):

6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C15H11F2N3
Número CAS:
1262888-28-7
Peso molecular:
271.26
Número MDL:
MFCD16962292
Código UNSPSC:
12352200
ID de substância PubChem:
329824722
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: 15 mg/mL (clear solution)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2

InChI

1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)

chave InChI

AWIVHRPYFSSVOG-UHFFFAOYSA-N

Aplicação

Spautin-1 has been used as an autophagy inhibitor:
  • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
  • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
  • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Ações bioquímicas/fisiológicas

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.
Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Frases de perigo

H302,H318

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 7

1 of 7

Sigma-Aldrich

Sigma-Aldrich

SAE0107

3-Methyladenine Ready made solution

SDF-1 ALPHA human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sigma-Aldrich

SRP3276

SDF-1 ALPHA human

MHY1485 ≥95% (HPLC)

Sigma-Aldrich

SML0810

MHY1485

Leupeptin trifluoroacetate salt ≥90% (HPLC), microbial

Sigma-Aldrich

L2023

Leupeptin trifluoroacetate salt

Q-VD-OPh hydrate ≥95% (HPLC)

Sigma-Aldrich

SML0063

Q-VD-OPh hydrate

Bafilomicina A1 ≥90% (HPLC)

Sigma-Aldrich

B1793

Bafilomicina A1

Cloroquina powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Cloroquina

V Vasilca et al.
Analytical biochemistry, 549, 58-65 (2018-03-17)
Screening assays performed against membrane protein targets (e.g. phage display) are hampered by issues arising from protein expression and purification, protein stability in detergent solutions and epitope concealment by detergent micelles. Here, we have studied a fast and simple method
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid
Ge Yang et al.
Scientific reports, 7(1), 17970-17970 (2017-12-23)
Presenilin (PS1 or PS2) functions as the catalytic subunit of γ-secretase, which produces the toxic amyloid beta peptides in Alzheimer's disease (AD). The dependence of folding and structural stability of PSs on the lipophilic environment and mutation were investigated by
Kuntal Ganguly et al.
Drug delivery, 23(8), 2838-2851 (2015-11-05)
Microspheres of chitosan (CS) cross-linked with polyethylene glycol (PEG) were prepared by emulsion-cross-linking followed by the solvent evaporation technique. The formulations were characterized and subjected to in vitro and in vivo tests to assess cell growth, changes in cell morphology
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica