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SML0440

Sigma-Aldrich

Spautin-1

≥98% (HPLC)

Sinônimo(s):

6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43

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About This Item

Fórmula empírica (Notação de Hill):
C15H11F2N3
Número CAS:
1262888-28-7
Peso molecular:
271.26
Número MDL:
MFCD16962292
Código UNSPSC:
12352200
ID de substância PubChem:
329824722
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 15 mg/mL (clear solution)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2

InChI

1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)

chave InChI

AWIVHRPYFSSVOG-UHFFFAOYSA-N

Aplicação

Spautin-1 has been used as an autophagy inhibitor:
  • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
  • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
  • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Ações bioquímicas/fisiológicas

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.
Spautin-1 is an inhibitor of autophagy.
Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Frases de perigo

H302,H318

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
095M4603V
123M4612V
072M4627V

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Sigma-Aldrich

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Sigma-Aldrich

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MHY1485 ≥95% (HPLC)

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

SML0063

Q-VD-OPh hydrate

Bafilomicina A1 ≥90% (HPLC)

Sigma-Aldrich

B1793

Bafilomicina A1

Cloroquina powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Cloroquina

V Vasilca et al.
Analytical biochemistry, 549, 58-65 (2018-03-17)
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