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SML0810

Sigma-Aldrich

MHY1485

≥95% (HPLC)

Sinônimo(s):

4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

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About This Item

Fórmula empírica (Notação de Hill):
C17H21N7O4
Número CAS:
326914-06-1
Peso molecular:
387.39
Código UNSPSC:
12352200
NACRES:
NA.77

Ensaio

≥95% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear (warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[N+](=O)([O-])c1ccc(cc1)Nc2nc(nc(n2)N4CCOCC4)N3CCOCC3

InChI

1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)

chave InChI

MSSXBKQZZINCRI-UHFFFAOYSA-N

Aplicação

MHY1485 has been used:
  • to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
  • to inhibit autophagy
  • as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Ações bioquímicas/fisiológicas

MHY1485 binds to the mammalian target of rapamycin (mTOR) and stimulates its action. MHY1485 has the ability to penetrate the cell. It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts.
MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
MHY1485 is mTOR activator: autophagy inhibitor.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
116M4762V
075M4732V
113M4757V

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MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling
Yang Bo, et al.
Oncotarget, 8(8), 12775-12775 (2017)
O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5
Wu N, et al.
Journal of Cellular and Molecular Medicine, 23(2), 1354-1362 (2019)
ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic
Gan W, et al.
BMC Cell Biology, 18(1), 22-22 (2017)
Duc-Vinh Pham et al.
Journal of experimental & clinical cancer research : CR, 41(1), 9-9 (2022-01-07)
Adiponectin, the most abundant adipokine derived from adipose tissue, exhibits a potent suppressive effect on the growth of breast cancer cells; however, the underlying molecular mechanisms for this effect are not completely understood. Fatty acid metabolic reprogramming has recently been
MHY1485 activates mTOR and protects osteoblasts from dexamethasone
Zhao S, et al.
Biochemical and biophysical research communications, 481(3-4), 212-218 (2016)
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Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

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