M9281
3-Methyladenine
autophagy inhibitor
Sinônimo(s):
3-MA, 6-Amino-3-methylpurine
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About This Item
Fórmula empírica (Notação de Hill):
C6H7N5
Número CAS:
Peso molecular:
149.15
Beilstein:
146087
Número CE:
Número MDL:
Código UNSPSC:
41106305
ID de substância PubChem:
NACRES:
NA.51
Produtos recomendados
fonte biológica
synthetic (organic)
Nível de qualidade
Ensaio
≥99% (HPLC)
Formulário
powder
pf
~300 °C (dec.) (lit.)
solubilidade
DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow
cadeia de caracteres SMILES
Cn1cnc(N)c2ncnc12
InChI
1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
chave InChI
FSASIHFSFGAIJM-UHFFFAOYSA-N
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Categorias relacionadas
Aplicação
3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
3-Methyladenine has been used as an autophagy inhibitor:
- to determine the expressions of autophagy-related genes (Beclin 1, light chain 3 (LC3) and p62) using the transfected human bone marrow mesenchymal stem cells (BM-MSCs)
- with cisplatin to study the inhibition of autophagy influenced cisplatin-induced apoptosis in A2780cp cells
- to study the interplay between colistin-induced autophagy and apoptosis
Standard for detection of nucleic acid methylation during carcinogenesis.
Ações bioquímicas/fisiológicas
3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).
Nota de preparo
This product is soluble in DMF (10 mg/mL; may require gentle heating). It is also soluble in water, 95% ethanol, or 1 N NaOH at 30 mg/mL with heating, but upon cooling, the product precipitates from solution. Solutions of 3-MA may be prepared in DMSO at 100 mM.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Artigos
We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance
High titer lentiviral particles for LC3 variants used for live cell analysis of cellular autophagy.
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