5.00554

MHY1485

≥97% (HPLC), solid, mTOR activator, Calbiochem^®

• Sinônimo(s): mTOR Activator, MHY1485, 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III
• Fórmula empírica (Notação de Hill): C₁₇H₂₁N₇O₄
• Número CAS: 326914-06-1
• Peso molecular: 387.39
• Número MDL: MFCD06591335
• Código UNSPSC: 12352200
• ID de substância PubChem: 2026662
• NACRES: NA.77

Propriedades

• Nome do produto: mTOR Activator, MHY1485,
• Ensaio: ≥97% (HPLC)
• Nível de qualidade: 100
• Formulário: solid
• potência: ~2 μM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: pale yellow
• solubilidade: DMSO: 12.5 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O
• chave InChI: VHYUALWDIXAVIZ-UHFFFAOYSA-N

Descrição

Descrição geral

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

Aplicação

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

Ações bioquímicas/fisiológicas

Cell permeable: yes

Reversible: yes

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Choi, Y. J., et al. 2012. PLoS. One.7, e43418.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable