1.07185

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

• Sinônimo(s): Pepsin
• Número CAS: 9001-75-6
• Peso molecular: 35000
• Número MDL: MFCD00081840
• Código UNSPSC: 12352204
• Número do índice EC: 232-629-3
• NACRES: NA.21

Propriedades

• pH: 4.0-5.0 (20 °C, 10 g/L in H₂O)
• solubilidade: 10 g/L
• densidade volumétrica: 380‑420 kg/m³
• temperatura de armazenamento: 2-30°C

Descrição

Aplicação

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

Ações bioquímicas/fisiológicas

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

Nota de análise

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

Informações de segurança

• Pictogramas: GHS07,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H315 - H319 - H334 - H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable