1.01005

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate

EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, NF

• Sinônimo(s): 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate, Acetone chloroform, Chlorbutol, Chloretone, Chlorobutanol
• Fórmula empírica (Notação de Hill): C₄H₇Cl₃O · 0.5H₂O
• Número CAS: 6001-64-5
• Peso molecular: 186.46
• Número MDL: MFCD02179352
• Código UNSPSC: 12352104
• Número do índice EC: 200-317-6

Propriedades

• Agency: BP; JP; NF; Ph. Eur.
• Nível de qualidade: 500
• linha de produto: EMPROVE^® ESSENTIAL
• Formulário: solid
• pH: 4.5-6 (20 °C, 7.7 g/L in H₂O)
• p.e.: 167 °C/1013 hPa
• pf: 78 °C
• temperatura de transição: flash point 100 °C
• solubilidade: 7.7 g/L
• aplicação(ões): liquid formulation; ophthalmics; pharmaceutical
• temperatura de armazenamento: 15-25°C
• cadeia de caracteres SMILES: ClC(Cl)(Cl)C(O)(C)C.ClC(Cl)(Cl)C(O)(C)C.O
• InChI: 1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2
• chave InChI: WRWLCXJYIMRJIN-UHFFFAOYSA-N

Descrição

Descrição geral

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) is typically used as a preservative in pharmaceutical formulations. It has antimicrobial properties and is active against bacteria and fungi.

Informações legais

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

The substance 1.01005 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 212.0 °F - closed cup
• Ponto de fulgor (°C): 100 °C - closed cup