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PHR1304

Supelco

Butylated hydroxyanisole

Pharmaceutical Secondary Standard; Certified Reference Material

Synonim(y):

2(3)-t-Butyl-4-hydroxyanisole, 2(3)-t-Butylhydroquinone monomethyl ether, BHA

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About This Item

Wzór liniowy:
(CH3)3CC6H3(OCH3)OH
Numer CAS:
25013-16-5
Masa cząsteczkowa:
180.24
Numer WE:
246-563-8
Numer MDL:
MFCD01779059
Kod UNSPSC:
41116107
NACRES:
NA.24

klasa czystości

certified reference material
pharmaceutical secondary standard

Poziom jakości

300

agency

traceable to Ph. Eur. B1212000
traceable to USP 1083008

gęstość pary

6.2 (vs air)

rodzina API

butylhydroxyanisole

Certyfikat analizy

current certificate can be downloaded

temp. samozapłonu

599 °F

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

58-60 °C (lit.)

Zastosowanie

pharmaceutical (small molecule)

Format

neat

temp. przechowywania

2-30°C

ciąg SMILES

O(C)c1cc(c(cc1)O)C(C)(C)C

InChI

1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3

Klucz InChI

MRBKEAMVRSLQPH-UHFFFAOYSA-N

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Opis ogólny

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Zastosowanie

Butylated hydroxyanisole (BHA) may be used as a reference standard for the determination of the analyte in pharmaceutical creams by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB3751 in the slot below. This is an example certificate only and may not be the lot that you receive.
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Piktogramy

Environment
GHS09

Zwroty wskazujące rodzaj zagrożenia

H411

Zwroty wskazujące środki ostrożności

P273 - P391 - P501

Klasyfikacja zagrożeń

Aquatic Chronic 2

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

241.9 °F - Pensky-Martens closed cup

Temperatura zapłonu (°C)

116.6 °C - Pensky-Martens closed cup

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Determination of miconazole in pharmaceutical creams using internal standard and second derivative spectrophotometry.
Wrobel K, et al.
Journal of Pharmaceutical and Biomedical Analysis, 20(1-2), 99-105 (1999)
[Modification of the processes of chemical mutagenesis and carcinogenesis by synthetic phenol antioxidants such as butylated hydroxyanisole].
K Demkowicz-Dobrzański et al.
Postepy biochemii, 38(1), 37-42 (1992-01-01)
H Verhagen et al.
Chemico-biological interactions, 80(2), 109-134 (1991-01-01)
Butylated hydroxyanisole (BHA) is a synthetic food antioxidant used to prevent oils, fats and shortenings from oxidative deterioration and rancidity. This review depicts the current knowledge on BHA. The physical and chemical characteristics of BHA are summarized and its function
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 137-151 (1996-01-01)
Butylated hydroxyanisole (BHA), at high doses, has been found to induce forestomach squamous cell carcinomas in rodents, but not glandular cell or other types of neoplasms. BHA is not DNA-reactive, and the epigenetic mechanism of tumor formation involves cytotoxicity and
G M Williams
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 24(10-11), 1163-1166 (1986-10-01)
Studies on the potential genotoxicity and epigenetic effects of BHA are reviewed. BHA was not DNA-reactive, but studies showed that it did have an effect on membrane systems, blocking exchange between hepatocytes and epithelial cells. The available data strongly suggest
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