Epigenetic promoting effects of butylated hydroxyanisole.

Studies on the potential genotoxicity and epigenetic effects of BHA are reviewed. BHA was not DNA-reactive, but studies showed that it did have an effect on membrane systems, blocking exchange between hepatocytes and epithelial cells. The available data strongly suggest that BHA is an epigenetic carcinogen that produces forestomach neoplasms through a promoting effect. Standard food safety procedures are suggested as appropriate for setting safe levels of exposure.