R4393

ロキシトロマイシン

95.0-102.0% (HPLC)

• 別名: エリスロマイシン 9-(-O-[2-メトキシエトキシ]メチルオキシム)
• 実験式（ヒル表記法）: C₄₁H₇₆N₂O₁₅
• CAS番号: 80214-83-1
• 分子量: 837.05
• MDL番号: MFCD00214389
• UNSPSCコード: 51282308
• PubChem Substance ID: 24899369
• NACRES: NA.85

特性

• アッセイ: 95.0-102.0% (HPLC)
• 形状: powder or crystals
• 溶解性: chloroform: soluble 10 mg/mL
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: protein synthesis | interferes
• 保管温度: 2-8°C
• SMILES記法: CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)\C(C)C(O)C1(C)O
• InChI: 1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+
• InChI Key: RXZBMPWDPOLZGW-FEMONOMJSA-N

詳細

詳細

Chemical structure: macrolide

アプリケーション

Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is used to block bacterial protein synthesis. Clinically, it is used to treat respiratory tract, urinary and soft tissue infections. It has a similar antimicrobial spectrum as erythromycin, but is the preferred treatment for certain gram-negative bacteria, such as Legionella pneumophila.

生物化学的／生理学的作用

Roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane. It is similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, and clarithromycin. Roxithromycin binds to the subunit 50S of the bacterial ribosome, inhibiting the translocation of peptides.

半合成エリスロマイシン誘導体です。NADPHオキシダーゼの活性化を妨げ、細胞質成分の好中球膜への転位を変化させます。

包装

1g,10g

その他情報

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves