E0774

エリスロマイシン

meets USP testing specifications

• 別名: Erythromycin A
• 実験式（ヒル表記法）: C₃₇H₆₇NO₁₃
• CAS番号: 114-07-8
• 分子量: 733.93
• Beilstein: 75279
• EC Number: 204-040-1
• MDL番号: MFCD00084654
• UNSPSCコード: 51282304
• PubChem Substance ID: 24894374
• NACRES: NA.76

特性

• 認証: USP/NF; meets USP testing specifications
• 品質水準: 200
• フォーム: solid
• 光学活性: [α]/D -78 to --71°
• 溶解性: ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• アプリケーション: pharmaceutical (small molecule)
• 作用機序: protein synthesis | interferes
• SMILES記法: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
• InChI Key: ULGZDMOVFRHVEP-RWJQBGPGSA-N
• 遺伝子情報: human ... ABCB1(5243) , CYP3A4(1576) , MLNR(2862) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

詳細

詳細

Chemical structure: macrolide

アプリケーション

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

生物化学的／生理学的作用

作用機序：エリスロマイシンは、ペプチド転位ステップにおける伸長を阻害することで作用し、特に、細菌の70s rRNA複合体の50sサブユニットに結合することで、A-部位からP-部位へのアミノアシル転位を阻害します。

抗菌スペクトル：本製品は、グラム陰性細菌とグラム陽性細菌の両方に対して作用します。

注意

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

調製ノート

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable