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Merck

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Synonyme:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
  • Thale Cress(818265) ABC transporter B family member 1
  • cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
9(10H)-Acridanon, 99%,
Spezies
human
Hydrocortison, BioReagent, suitable for cell culture,
Spezies
human, mouse, rat
Hydrocortison -Lösung, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Spezies
human, mouse, rat
Hydrocortison, γ-irradiated, powder, BioXtra, suitable for cell culture,
Spezies
human, mouse, rat
Hydrocortison, ≥98% (HPLC),
Spezies
human, mouse, rat

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
Chlorsulfonylisocyanat, 98%,
Spezies
human
Ivermectin, ,
Spezies
mouse, human
Omeprazol, solid,
Spezies
human
Erythromycin, BioReagent, suitable for cell culture,
Spezies
mouse, human
Clotrimazol, ,
Spezies
mouse, human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Speziesreaktivität
hamster, human
Anwendung
ELISA
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

radioimmunoassay

western blot
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, mouse
Anwendung
affinity binding assay
flow cytometry

immunocytochemistry

immunohistochemistry

western blot
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
immunohistochemistry
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Speziesreaktivität
hamster, human
Anwendung
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
Anti-Glycoprotein (MDR) antibody, Mouse monoclonal, clone F4, purified from hybridoma cell culture,
Speziesreaktivität
hamster, human
Anwendung
flow cytometry
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot

Cell Lines

Produktnummer
Beschreibung
Spezies
Canine MDR1 Knockout, Human MDR1 Knockin MDCKII Cells, ,
Spezies
human
CAR Knockout HepaRG Cells, 1 vial,
Spezies
MDR1 Knockout Caco-2 Cells, one vial,
Spezies
human
MDR1 Knockout HepaRG Cells, 1 vial,
Spezies
human
MDR1/BCRP-Doppel-Knockout-Caco-2-Zellen, one vial,
Spezies
human

Kits

Produktnummer
Beschreibung
Spezies
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Spezies
human, mouse, rat

Small Molecule - Mixed Agonist/Antagonist

Produktnummer
Beschreibung
Spezies
Dexamethason, powder, BioReagent, suitable for cell culture, ≥97%,
Spezies
mouse, rat, human
Dexamethason, ≥98% (HPLC), powder,
Spezies
mouse, rat, human
Dexamethason, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Spezies
mouse, rat, human
Progesteron-Wasser, löslich, powder, BioReagent, suitable for cell culture,
Spezies
mouse, human, rat
Dexamethason, meets USP testing specifications,
Spezies
mouse, rat, human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human ABCB1,
Spezies
human