ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Synonyme:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Spezies:
Human ABCB1 (5243), Thale Cress ABCB1 (818265), cow ABCB1 (281585), Horse ABCB1 (100034074), domestic cat ABCB1 (493707), dog ABCB1 (403879), sheep ABCB1 (443367), Domestic Rabbit ABCB1 (100008914), domestic guinea pig Abcb1 (100733532), naked mole-rat Abcb1 (101702843)
UniProtKB-ID:
Gen-ID:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- Thale Cress(818265) ABC transporter B family member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
Produktnummer
Beschreibung
Spezies
Hydrocortison -Lösung, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Spezies
human, mouse, rat
Hydrocortison, γ-irradiated, powder, BioXtra, suitable for cell culture,
Spezies
human, mouse, rat
Small Molecule - Antagonist
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Speziesreaktivität
hamster, human
Anwendung
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, mouse
Anwendung
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Speziesreaktivität
hamster, human
Anwendung
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-Glycoprotein (MDR) antibody, Mouse monoclonal, clone F4, purified from hybridoma cell culture,
Speziesreaktivität
hamster, human
Anwendung
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Cell Lines
Produktnummer
Beschreibung
Spezies
Kits
Produktnummer
Beschreibung
Spezies
Small Molecule - Mixed Agonist/Antagonist
Produktnummer
Beschreibung
Spezies
Dexamethason, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Spezies
mouse, rat, human
Progesteron-Wasser, löslich, powder, BioReagent, suitable for cell culture,
Spezies
mouse, human, rat
esiRNA
Produktnummer
Beschreibung
Spezies