ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
同義詞:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
物種:
Human ABCB1 (5243), Thale Cress ABCB1 (818265), cow ABCB1 (281585), Horse ABCB1 (100034074), domestic cat ABCB1 (493707), dog ABCB1 (403879), sheep ABCB1 (443367), Domestic Rabbit ABCB1 (100008914), domestic guinea pig Abcb1 (100733532), naked mole-rat Abcb1 (101702843)
UniProtKB ID:
基因 ID:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- Thale Cress(818265) ABC transporter B family member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
產品編號
描述
物種
Small Molecule - Antagonist
Antibodies
產品編號
描述
物種活性
應用
抗p-糖蛋白(MDR) 小鼠抗, clone F4, ascites fluid,
物種活性
hamster, human
應用
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物種活性
human
應用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
物種活性
hamster, human
應用
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
抗-MDR1抗体，细胞外人类特异性Pgp，克隆号MC57, clone MC57, Chemicon®, from mouse,
物種活性
human
應用
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2, clone UIC2, Chemicon®, from mouse,
物種活性
human, primate
應用
flow cytometry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
Cell Lines
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Kits
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物種
Small Molecule - Mixed Agonist/Antagonist
產品編號
描述
物種
地塞米松, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
物種
mouse, rat, human
esiRNA
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物種