R2146

ラディシコール Diheterospora chlamydosporia由来

solid

• 別名: [1aS-(1aR*,2Z,4E,14*,15aR*)]-8-クロロ-1a,14,15,15a-テトラヒドロ-9,11-ジヒドロキシ-14-メチル-6H-オキシレノ[e][2]ベンゾキサシクロテトラデシン-6,12 (7H)-ジオン, モノルデン
• 実験式（ヒル表記法）: C₁₈H₁₇ClO₆
• CAS番号: 12772-57-5
• 分子量: 364.78
• MDL番号: MFCD06795865
• UNSPSCコード: 51111800
• PubChem Substance ID: 24899351
• NACRES: NA.77

特性

• 形状: solid
• 品質水準: 200
• 環境により配慮した代替製品スコア: old score: 15; new score: 9; Find out more about DOZN™ Scoring
• 環境により配慮した代替製品の特徴: Waste Prevention; Atom Economy; Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• 色: white to yellow-white
• 溶解性: ethanol: 10 mg/mL
• 抗生物質活性スペクトル: fungi
• 環境により配慮した代替製品カテゴリ: , Re-engineered
• 作用機序: enzyme | inhibits
• 保管温度: −20°C
• SMILES記法: C[C@@H]1C[C@H]2O[C@@H]2C=C\C=C\C(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1
• InChI: 1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
• InChI Key: WYZWZEOGROVVHK-GTMNPGAYSA-N
• 遺伝子情報: human ... HSP90AA1(3320) , SRC(6714) ; rat ... Src(83805)

詳細

アプリケーション

Radicicol from Diheterospora chlamydosporia has been used as an inhibitor of heat shock protein 90 (Hsp90):

• to study its effects on lifespan extension and health in Caenorhabditis elegans
• to study its effects on protein aggregation in yeast
• to study its effects on xanthone sensitized cancer cells

生物化学的／生理学的作用

Radicicol is an antifungal macrolactone antibiotic that is found in Diheterospora chlamydosporia, Chaetomium chiversii, and Monosporium bonorden. It functions as an inhibitor of tyrosine kinase and heat shock protein 90 (Hsp90). Radicicol is involved in the suppression of transformation of various proto-oncogenes such as Ras, Mos, and Src. It also suppresses the activity of mitogen-induced cyclooxygenase-2 (COX-2) and phosphoinositide-dependent kinase 1 (PDK1). Radicicol is involved in arresting the cell cycle at the G1-S phase. It exhibits ant-cancer and anti-angiogenic activity in vivo.

注意

光感受性

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H340,H350
• 注意書き: P202 - P264 - P280 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral - Carc. 1B - Muta. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable