C6643

クロフィブラート

liquid

• 別名: 2-(4-クロロフェノキシ)-2-メチルプロピオン酸エチル, 2-(4-クロロフェノキシ)-2-メチルプロピオン酸エチルエステル, 2-(4-クロロフェノキシ)イソ酪酸エチル
• 実験式（ヒル表記法）: C₁₂H₁₅ClO₃
• CAS番号: 637-07-0
• 分子量: 242.70
• Beilstein: 1913459
• EC Number: 211-277-4
• MDL番号: MFCD00000615
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278085
• NACRES: NA.77

特性

• フォーム: liquid
• 品質水準: 200
• 色: clear colorless
• 密度: 1.14 g/mL at 25 °C (lit.)
• オーガナイザー: Wyeth
• 保管温度: 2-8°C
• SMILES記法: CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
• InChI: 1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
• InChI Key: KNHUKKLJHYUCFP-UHFFFAOYSA-N
• 遺伝子情報: human ... PPARA(5465) ; mouse ... Ppara(19013)

詳細

アプリケーション

Clofibrate has been used:

• as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
• as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
• as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes

生物化学的／生理学的作用

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.

特徴および利点

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

包装

底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H318,H335
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): 235.4 °F - closed cup
• 引火点(℃): 113 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter