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Merck

PPARA

peroxisome proliferator-activated receptor alpha

Synonyms:
NR1C1, PPAR, PPARalpha, hPPAR
Species:
Human PPARA (5465), Mouse Ppara (19013), Rat Ppara (25747), Domestic Rabbit PPARA (100009308), naked mole-rat Ppara (101725514), domestic guinea pig Ppara (100135604), cow PPARA (281992), sheep PPARA (100190976), Goat PPARA (100861393), chicken PPARA (374120) ...More
UniProtKB ID:
Q07869, B0G0X3, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1
Gene ID:
  • Human(5465) Summary: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
  • Mouse(19013) peroxisome proliferator activated receptor alpha
  • Rat(25747) peroxisome proliferator activated receptor alpha
  • Domestic Rabbit(100009308) peroxisome proliferator-activated receptor alpha
  • naked mole-rat(101725514) peroxisome proliferator-activated receptor alpha
  • domestic guinea pig(100135604) peroxisome proliferator activated receptor alpha
  • cow(281992) peroxisome proliferator-activated receptor alpha
  • sheep(100190976) peroxisome proliferator-activated receptor alpha
  • Goat(100861393) peroxisome proliferator-activated receptor alpha
  • chicken(374120) peroxisome proliferator-activated receptor alpha
  • dog(403654) peroxisome proliferator-activated receptor alpha
  • domestic cat(101095837) peroxisome proliferator-activated receptor alpha
  • Horse(100049840) peroxisome proliferator-activated receptor alpha
  • domestic cat(100049013) peroxisome proliferator-activated receptor alpha

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Small Molecule - Activator

Product Number
Description
Species
F6020
Fenofibrate, ≥99%, powder,
Species
human
197777
2-(p-Chlorophenoxy)-2-methylpropionic acid, 97%,
Species
mouse, human
C7081
WY-14643, ,
Species
rat, human, mouse
B7273
Bezafibrate, ≥98%, solid,
Species
mouse, human

Small Molecule - Agonist

Product Number
Description
Species
F0048000
Fenofibrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
1269447
Fenofibrate, United States Pharmacopeia (USP) Reference Standard,
Species
human
PHR1246
Fenofibrate, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
90568
Fenofibric acid, analytical standard,
Species
human
796565
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid, 95%,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
T2573
Troglitazone, ≥98% (HPLC),
Species
human
G3295
GW0742, ≥98% (HPLC),
Species
human
O0383
N-Oleoylethanolamine, ~98% (TLC),
Species
human, mouse, rat

Antibodies

Product Number
Description
Species Reactivity
Application
SAB2104354
Anti-PPARA, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, goat, guinea pig, horse, human, rabbit
Application
western blot
SAB1402875
Monoclonal Anti-PPARA antibody produced in mouse, clone 1A8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
ABE2888
Anti-phospho PPAR alpha (Ser73), from rabbit,
Species Reactivity
bovine, human, mouse, rat
Application
dot blot
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
MAB3890
Anti-PPAR α Antibody, ascites fluid, Chemicon®,
Species Reactivity
human, mouse
Application
ELISA
immunocytochemistry
western blot
HPA067049
Anti-PPARA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot

Proteins

Product Number
Description
Species
SRP2134
PPARα isotype, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
SRP2054
PPARα, ligand binding domain (170-468) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human
SRP2135
PPARα isotype, ligand binding domain, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human
SRP2043
PPAR, α human, recombinant, expressed in E. coli, ≥75% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EHU151821
MISSION® esiRNA, targeting human PPARA,
Species
human