PHR1702

プロピオン酸フルチカゾン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: (6α,11β,16α,17α)-6,9-ジフルオロ-11-ヒドロキシ-16-メチル-3-オキソ-17-(1-オキソプロポキシ)アンドロスタ-1,4-ジエン-17-カルボチオ酸 S-(フルオロメチル)エステル
• 実験式（ヒル表記法）: C₂₅H₃₁F₃O₅S
• CAS番号: 80474-14-2
• 分子量: 500.57
• MDL番号: MFCD00866007
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823565
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 587; traceable to Ph. Eur. Y0000284; traceable to USP 1285873
• APIファミリー: fluticasone
• CofA: current certificate can be downloaded
• 包装: pkg of 200 mg
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF
• InChI: 1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
• InChI Key: WMWTYOKRWGGJOA-CENSZEJFSA-N
• 遺伝子情報: human ... NR3C1(2908)

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluticasone Propionate, a neutral, highly potent trifluorinated corticosteroid, is a component of aqueous nasal sprays. It shows potent topical anti-inflammatory activity and is highly efficient in suppressing the nasal symptoms associated with rhinitis and asthma.

アプリケーション

Fluticasone Propionate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

プロピオン酸フルチカゾンは、第二世代の糖質コルチコイドです。喘息用の抗炎症剤として使用されます。糖質コルチコイド受容体を介して濃度依存的に、好酸球のアポトーシスを促進します。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAB9941 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H361f,H373
• 注意書き: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Repr. 2 - STOT RE 2
• ターゲットの組織: Endocrine system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable