PHR1265

カルベジロール

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 1-(9H-カルバゾール-4-イルオキシ)-3-[[2-(2-メトキシフェノキシ)エチル]アミノ]-2-プロパノール, BM-14190
• 実験式（ヒル表記法）: C₂₄H₂₆N₂O₄
• CAS番号: 72956-09-3
• 分子量: 406.47
• MDL番号: MFCD00864692
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823261
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. Y0001427; traceable to USP 1096622
• APIファミリー: carvedilol
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC
• InChI: 1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
• InChI Key: OGHNVEJMJSYVRP-UHFFFAOYSA-N
• 遺伝子情報: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Carvedilol is a lipophilic β₁- and β₂-adrenoreceptor antagonist that exhibits antioxidant and antiproliferative properties. It is prescribed as a medicine for the treatment of hypertension, stable angina pectoris, post myocardial infarction with left ventricular dysfunction and all degrees of symptomatic chronic heart failure.

アプリケーション

Carvedilol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

カルベジロ-ルはα1遮断活性を有する非選択的βアドレナリン遮断薬です。カルベジロ-ルは、特に心不全および高血圧症の治療に用いられます。左室駆出率を改善することが知られており、死亡率を低下させられる可能性があります。

注意

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

脚注

To see an example of a Certificate of Analysis for this material enter LRAA9063 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS08,GHS09
• シグナルワード: Warning
• 危険有害性情報: H373,H411
• 注意書き: P260 - P273 - P314 - P391 - P501
• 危険有害性の分類: Aquatic Chronic 2 - STOT RE 2
• ターゲットの組織: Liver,spleen,Uterus (including cervix),Adrenal gland
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable