PHR1734

Ritonavir

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: Ritonavir, 10-Hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid, 5-thiazolylmethyl ester, [5S-(5R*, 8R*, 10R*, 11R*)], 1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
• 実験式（ヒル表記法）: C₃₇H₄₈N₆O₅S₂
• CAS番号: 155213-67-5
• 分子量: 720.94
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• 由来生物: synthetic
• 品質水準: 300
• グレード: certified reference material; pharmaceutical secondary standard
• 認証: BP; EP; USP; traceable to Ph. Eur. Y0000714; traceable to USP 1604803
• 蒸気圧: <0.0000001 kPa ( 25 °C)
• APIファミリー: ritonavir
• 形状: powder
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• 保管条件: protect from light
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 色: white to tan
• 溶解性: acetonitrile: slightly soluble; ethanol: freely soluble; methanol: freely soluble; methylene chloride: freely soluble; water: practically insoluble
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 輸送温度: ambient
• 保管温度: 2-30°C
• InChI: 1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
• InChI Key: NCDNCNXCDXHOMX-XGKFQTDJSA-N

詳細

詳細

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Ritonavir belongs to the group of protease inhibitors, which block the part of HIV called protease. Its mode of action involves binding to the protease active site and inhibiting the activity of the enzyme.

アプリケーション

Ritonavir may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAB9120 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H312 + H332
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable