PHR1700

リバビリン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 1-β-D-リボフラノシル-1,2,4-トリアゾール-3-カルボキシアミド
• 実験式（ヒル表記法）: C₈H₁₂N₄O₅
• CAS番号: 36791-04-5
• 分子量: 244.20
• MDL番号: MFCD00058564
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823563
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 593; traceable to Ph. Eur.; traceable to USP 1602706
• APIファミリー: ribavirin
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
• InChI Key: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• 遺伝子情報: human ... IMPDH1(3614)

詳細

詳細

プリンヌクレオチド生合成におけるイミダゾールヌクレオチド中間体の類似体。

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

アプリケーション

Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

広範なヒトウイルス感染症に用いられる抗ウイルス薬で、特にC型慢性肝炎、HIV、アデノウイルスに頻用されます。その代謝産物であるリバビリン5'-リン酸は、イノシン一リン酸(IMP)デヒドロゲナーゼのインヒビターですが、他の多くの作用機序についても、実験に基づく根拠により裏付けられています。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H341,H360FD
• 注意書き: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Muta. 2 - Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable