C3045

Colesterolo

powder, BioReagent, suitable for cell culture, ≥99%

• Sinonimo/i: 3β-idrossi-5-colestene, 5-colestene-3β-olo
• Formula empirica (notazione di Hill): C₂₇H₄₆O
• Numero CAS: 57-88-5
• Peso molecolare: 386.65
• Beilstein: 1915888
• Numero CE: 200-353-2
• Numero MDL: MFCD00003646
• Codice UNSPSC: 12352211
• eCl@ss: 39023139
• ID PubChem: 24892329
• NACRES: NA.75

Proprietà

• Origine biologica: ovine wool
• Nome Commerciale: BioReagent
• Saggio: ≥99%
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• P. ebollizione: 360 °C (lit.)
• Punto di fusione: 147-149 °C (lit.)
• Solubilità: H₂O: 0.002 mg/mL; Tween: soluble; ethanol: soluble; serum: soluble
• Densità: 1.067 g/mL at 25 °C (lit.)
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1; HVYWMOMLDIMFJA-DPAQBDIFSA-N
• Informazioni sul gene: human ... POLA1(5422) , TOP2A(7153) ; rat ... Ar(24208) , Polb(29240)

Descrizione

Descrizione generale

Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.

Applicazioni

Cholesterol has been used:

• as a medium supplement in chorionic villous tissue culture form placenta
• as a component of hormone pellet for implantation in mice ovary
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Azioni biochim/fisiol

Componente principale di tutte le membrane biologiche; il colesterolo rappresenta il 25% circa dei lipidi cerebrali totali.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)