TOP2A
topoisomerase (DNA) II alpha 170kDa
Sinónimos:
TOP2, TP2A
Especie:
Human TOP2A (7153), Mouse Top2a (21973), Rat Top2a (360243), Zebrafish top2a (323733), dog TOP2A (480525), domestic cat TOP2A (101083813), chicken TOP2A (395570), domestic guinea pig Top2a (100730168), Domestic Rabbit TOP2A (100357676), cow TOP2A (787696)
ID UniProtKB:
ID del gen:
- Human(7153) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
- Mouse(21973) topoisomerase (DNA) II alpha
- Rat(360243) topoisomerase (DNA) II alpha
- Zebrafish(323733) topoisomerase (DNA) II alpha
- dog(480525) topoisomerase (DNA) II alpha 170kDa
- domestic cat(101083813) topoisomerase (DNA) II alpha 170kDa
- chicken(395570) topoisomerase (DNA) II alpha 170kDa
- domestic guinea pig(100730168) topoisomerase (DNA) II alpha 170kDa
- Domestic Rabbit(100357676) topoisomerase (DNA) II alpha 170kDa
- cow(787696) topoisomerase (DNA) II alpha 170kDa
- sheep(101108762) topoisomerase (DNA) II alpha 170kDa
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Topoisomerase II Antibody, clone 3C3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
TOP2A (Topoisomerase IIα) Rabbit Monoclonal Antibody, clone RM394, affinity purified immunoglobulin,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-TOP2A antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
ELISA
western blot
western blot
Small Molecule - Inhibitor
Referencia del producto
Descripción
Especie
Doxorrubicina hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Proteins
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Especie