D0125000

Daunorubicin hydrochloride

European Pharmacopoeia (EP) Reference Standard

• Synonym(s): Daunomycin hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₀ · HCl
• CAS Number: 23541-50-6
• Molecular Weight: 563.98
• Beilstein/REAXYS Number: 4229221
• MDL number: MFCD04974507
• UNSPSC Code: 41116107
• PubChem Substance ID: 329798585
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: daunorubicin
• manufacturer/tradename: EDQM
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
• InChI: 1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
• InChI key: GUGHGUXZJWAIAS-QQYBVWGSSA-N
• Gene Information: human ... TOP2A(7153)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Daunorubicin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H341,H351,H360FD
• pcodes: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3