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T7165

Sigma-Aldrich

Tyrphostin 23

≥98%

Sinônimo(s):

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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About This Item

Fórmula empírica (Notação de Hill):
C10H6N2O2
Número CAS:
118409-57-7
Peso molecular:
186.17
Número MDL:
MFCD00133899
Código UNSPSC:
12352200
ID de substância PubChem:
24278041
NACRES:
NA.77

fonte biológica

synthetic (organic)

Ensaio

≥98%

forma

powder

potência

35 μM IC50

solubilidade

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

chave InChI

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Informações sobre genes

human ... CDK2(1017)

Aplicação

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Ações bioquímicas/fisiológicas

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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The plant defense elicitor cryptogein triggers well-known biochemical events of early signal transduction at the plasma membrane of tobacco (Nicotiana tabacum) cells, but microscopic observations of cell responses related to these early events were lacking. We determined that internalization of
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