Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

Visualizar Toda a Documentação

C4859

Sigma-Aldrich

Cycloheximide solution

Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture

Sinônimo(s):

CHX

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C15H23NO4
Número CAS:
66-81-9
Peso molecular:
281.35
Número MDL:
MFCD00082346
Código UNSPSC:
12352111
ID de substância PubChem:
24892732
NACRES:
NA.77

fonte biológica

microbial

Nível de qualidade

300

descrição

suitable for testing specifications (CHO C. growth inhibitor)

Formulário

solution

concentração

100 mg/mL in DMSO

solubilidade

DMSO: soluble

espectro de atividade do antibiótico

fungi
yeast

Modo de ação

protein synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

chave InChI

YPHMISFOHDHNIV-FSZOTQKASA-N

Informações sobre genes

human ... FKBP1A(2280) , PIN1(5300)

Procurando produtos similares? Visita Guia de comparação de produtos

Categorias relacionadas

Especificidade

Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.

Ações bioquímicas/fisiológicas

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Hygroscopic. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

188.6 °F - closed cup

Ponto de fulgor (°C)

87 °C - closed cup

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
128M4081V
11180626
028M4045V
11170828
126M4069V

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 3

1 of 3

Anti-BRCA1 (Ab-4) Mouse mAb (SD118) liquid, clone SD118, Calbiochem®

Sigma-Aldrich

OP107

Anti-BRCA1 (Ab-4) Mouse mAb (SD118)

Anti-STAT1 antibody produced in rabbit Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA000982

Anti-STAT1 antibody produced in rabbit

Endosidin2 ≥98% (HPLC)

Sigma-Aldrich

SML1681

Endosidin2

Hye-Yeoung Yun et al.
PLoS biology, 17(7), e3000367-e3000367 (2019-07-20)
Human papillomaviruses (HPVs) are causative agents of various diseases associated with cellular hyperproliferation, including cervical cancer, one of the most prevalent tumors in women. E7 is one of the two HPV-encoded oncoproteins and directs recruitment and subsequent degradation of tumor-suppressive
Konstantinos Boulias et al.
Molecular cell, 75(3), 631-643 (2019-07-08)
mRNAs are regulated by nucleotide modifications that influence their cellular fate. Two of the most abundant modified nucleotides are N6-methyladenosine (m6A), found within mRNAs, and N6,2'-O-dimethyladenosine (m6Am), which is found at the first transcribed nucleotide. Distinguishing these modifications in mapping
Matthias Rottmann et al.
Science (New York, N.Y.), 329(5996), 1175-1180 (2010-09-04)
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates
Anna Duarri et al.
Annals of neurology, 72(6), 870-880 (2013-01-03)
To identify the causative gene for the neurodegenerative disorder spinocerebellar ataxia type 19 (SCA19) located on chromosomal region 1p21-q21. Exome sequencing was used to identify the causal mutation in a large SCA19 family. We then screened 230 ataxia families for
V O Kaminskyy et al.
Cell death & disease, 4, e522-e522 (2013-03-09)
TNF-related apoptosis-inducing ligand (TRAIL) is a promising cytokine for killing tumor cells. However, a number of studies have demonstrated that different cancer cells resist TRAIL treatment and, moreover, TRAIL can promote invasion and metastasis in resistant cells. Here we report
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica