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Merck

CDK2

cyclin-dependent kinase 2

Synonyms:
p33(CDK2)
Species:
Human CDK2 (1017), Mouse Cdk2 (12566), Rat Cdk2 (362817), Zebrafish cdk2 (406715), cow CDK2 (519217), chicken CDK2 (100529062), dog CDK2 (606931), domestic cat CDK2 (101093368), domestic guinea pig Cdk2 (100714324), naked mole-rat Cdk2 (101725353) ...More
UniProtKB ID:
P24941, A8K7C6, O75100
Gene ID:
  • Human(1017) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(12566) cyclin-dependent kinase 2
  • Rat(362817) cyclin dependent kinase 2
  • Zebrafish(406715) cyclin-dependent kinase 2
  • cow(519217) cyclin-dependent kinase 2
  • chicken(100529062) cyclin-dependent kinase 2
  • dog(606931) cyclin-dependent kinase 2
  • domestic cat(101093368) cyclin-dependent kinase 2
  • domestic guinea pig(100714324) cyclin-dependent kinase 2
  • naked mole-rat(101725353) cyclin-dependent kinase 2
  • Goat(100860751) cyclin-dependent kinase 2
  • sheep(100216433) cyclin-dependent kinase 2
  • Domestic Rabbit(100134865) cyclin-dependent kinase 2

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4500050
Anti-CDK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
PLA0213
Rabbit anti-CDK2 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
AMAB91497
Monoclonal Anti-CDK2 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL7990, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB5702465
[KO Validated]Anti-CDK2 Antibody, clone 10E0N5, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
SAB4300110
Anti-phospho-CDK2 (pThr160) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
T7165
Tyrphostin 23, ≥98%,
Species
human
N4286
NU2058, >98% (HPLC),
Species
human
P0453
Piceatannol, powder,
Species
human
363057
6-O-Methylguanine, 97%,
Species
human
T7665
Tyrphostin 51, ≥98%,
Species
human

Proteins

Product Number
Description
Species
C0495
CDK2/Cyclin A2, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
SRP5010
CDK2/CyclinA1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
23-024-M
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
Species
human
14-450-M
Cdk1/cyclin B Protein, active, 10 µg, Active, C-terminal His6-tagged human full length Cdk1 & N-terminal GST-tagged human full length Cyclin B, for use in Kinase Assays.,
Species
human
14-475-M
Cdk2/Cyclin E Protein, active, 10 µg, Active complex of recombinant full length human Cdk2 containing a C-terminal His6-tag & recombinant full-length human Cyclin E containing an N-terminal GST-tag. For use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
EHU061761
MISSION® esiRNA, targeting human CDK2,
Species
human
EMU085451
MISSION® esiRNA, targeting mouse Cdk2,
Species
mouse