T6700
TRAM-34
≥98% (HPLC), solid
Sinônimo(s):
1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
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About This Item
Fórmula empírica (Notação de Hill):
C22H17ClN2
Número CAS:
Peso molecular:
344.84
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
solid
cor
off-white
solubilidade
DMSO: 2 mg/mL
H2O: insoluble
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
chave InChI
KBFUQFVFYYBHBT-UHFFFAOYSA-N
Aplicação
TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.
Ações bioquímicas/fisiológicas
TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.
TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.
Características e benefícios
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Nota de preparo
TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral - Aquatic Chronic 4
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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