I5904
Iberiotoxin, recombinant from Mesobuthus tamulus
≥98% (HPLC), recombinant, expressed in E. coli
Sinônimo(s):
IbTX
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About This Item
Fórmula empírica (Notação de Hill):
C179H276N50O56S7
Peso molecular:
4248.86
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
recombinante
expressed in E. coli
Nível de qualidade
Ensaio
≥98% (HPLC)
temperatura de armazenamento
−20°C
Amino Acid Sequence
Glp-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln [Disulfide Bridges: 7−28; 13−33; 17−35]
Aplicação
Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K+ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca2+- activated K+ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.
Ações bioquímicas/fisiológicas
The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.
Exhibits the same activity as the natural form of the toxin
Características e benefícios
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Nota de preparo
Soluble in aqueous buffers. Stock solutions of 1 μM can be aliquoted and stored at -20 °C for up to 3 months.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
Código de classe de armazenamento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de risco de água (WGK)
WGK 3
Equipamento de proteção individual
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Certificados de análise (COA)
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