C2499

CP-339818

≥98% (HPLC)

• Sinônimo(s): N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
• Fórmula empírica (Notação de Hill): C₂₁H₂₄N₂ · HCl
• Número CAS: 478341-55-8
• Peso molecular: 340.89
• Número MDL: MFCD09878238
• Código UNSPSC: 12352200
• ID de substância PubChem: 329775008
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to off-white
• solubilidade: DMSO: >10 mg/mL
• originador: Wyeth
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.CCCCC\N=C1/C=CN(Cc2ccccc2)c3ccccc13
• InChI: 1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H/b22-20+;
• chave InChI: JIRISCAPZWLWCG-QPNALZDCSA-N

Descrição

Ações bioquímicas/fisiológicas

CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.

Características e benefícios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable