D8174

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F_2α

≥98% (HPLC), solution, thromboxane A2 agonist

• Sinônimo(s): U-46619, U46619
• Fórmula empírica (Notação de Hill): C₂₁H₃₄O₄
• Número CAS: 56985-40-1
• Peso molecular: 350.49
• Beilstein: 4267334
• Número MDL: MFCD00135238
• Código UNSPSC: 12352211
• ID de substância PubChem: 24894197
• NACRES: NA.77

Propriedades

• Nome do produto: 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F_2α, solution, 10 mg/mL in methyl acetate
• Formulário: solution
• Nível de qualidade: 200
• concentração: 10 mg/mL in methyl acetate
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCCCC[C@H](O)\C=C\[C@H]1C2CC(CO2)[C@@H]1C\C=C/CCCC(O)=O
• InChI: 1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1
• chave InChI: LQANGKSBLPMBTJ-REGKDVDGSA-N

Descrição

Descrição geral

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α is an endoperoxide/thromboxane analog.

Aplicação

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α has been used:

• to induce aortic smooth muscle (SM) contraction in mice deficient in myosin light chain 9 (Myl9) gene
• to induce contraction as part of vascular reactivity experiments using mice aorta
• as a thromboxane/prostaglandin agonist to study the effect of dithiothreitol (DTT) on mice arterial vessel viability

Ações bioquímicas/fisiológicas

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α is a thromboxane A2 agonist. It is useful in in vitro experiments to induce shape change, aggregation, secretion, phosphoinositide hydrolysis, and protein phosphorylation in platelets. It also causes an elevation in the cytosolic Ca⁺⁺ levels slightly affecting the cyclic adenosine monophosphate (cAMP) formation. It acts as a potent stimulator of vascular cell adhesion molecule-1 (VCAM-1), which mediates leukocyte adhesion to the endothelium.

Características e benefícios

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H319,H336
• Declarações de precaução: P210 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Órgãos-alvo: Central nervous system
• Perigos de suplementos: EUH066
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 14.0 °F
• Ponto de fulgor (°C): -10 °C
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter