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T0557

Sigma-Aldrich

Taurodesoxicolato de sódio

BioXtra, ≥97% (TLC)

Sinônimo(s):

Ácido 2-([3α,12α-di-hidroxi-24-oxo-5β-colan-24-il]amino) etanossulfônico, Ácido taurodesoxicólico

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About This Item

Fórmula linear:
C26H44NO6SNa · xH2O
Número CAS:
207737-97-1
Peso molecular:
521.69 (anhydrous basis)
Beilstein:
3901204
Número MDL:
MFCD00149238
Código UNSPSC:
12161900
ID de substância PubChem:
24899897
NACRES:
NA.25

descrição

anionic

Nível de qualidade

200

linha de produto

BioXtra

Ensaio

≥97% (TLC)

peso molecular

micellar avg mol wt 3100

número de agregação

6

Impurezas

≤0.002% Phosphorus (P)
≤0.1% Insoluble matter

CMC

1-4 mM (20-25°C)

solubilidade

H2O: 0.5 M, clear, colorless to faintly yellow

traços de ânion

chloride (Cl-): ≤0.5%
sulfate (SO42-): ≤0.05%

traços de cátion

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.01%
Mg: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

cadeia de caracteres SMILES

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;;/m1../s1

chave InChI

OLPIZAYYAVQETM-GGPRKOIFSA-M

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Descrição geral

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Aplicação

Detergente aniônico relacionado a sais biliares é usado para o isolamento de proteínas de membrana, incluindo proteínas da membrana mitocondrial interna.
Sodium tauroursodeoxycholate has been used in a study to assess short-term feedback regulation of bile salt uptake in rodent liver. It has also been used in a study to investigate its potential to resolve endoplasmic reticulum (ER) stress in intestinal epithelial cells. It is also used for isolation of membrane proteins including inner mitochondrial membrane proteins.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLCD5024
SLBZ4144
SLBW6098
SLBS4174
SLBQ8826V

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Emanuel Berger et al.
Biochemical and biophysical research communications, 409(4), 610-615 (2011-05-25)
Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to
Stefanie Mühlfeld et al.
Hepatology (Baltimore, Md.), 56(6), 2387-2397 (2012-07-19)
The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcellular localization of Ntcp was
Kalinne Kelly Lima Gadelha et al.
Experimental physiology, 104(2), 199-208 (2018-12-19)
What is the central question of this study? Is the responsiveness of isolated segments of the rat oesophagus to contractile or relaxant stimuli susceptible to acute luminal exposure of the oesophagus to an acid solution that contains pepsin and bile
Salma Alavi et al.
Cell, 181(7), 1533-1546 (2020-07-08)
The gut microbiome is the resident microbial community of the gastrointestinal tract. This community is highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal pathogens is poorly understood. Using transplantation of human microbiomes into several animal models
Susanne Naumann et al.
Nutrients, 11(6) (2019-06-28)
Dietary fibres are reported to interact with bile acids, preventing their reabsorption and promoting their excretion into the colon. We used a method based on in vitro digestion, dialysis, and kinetic analysis to investigate how dietary fibre enriched food ingredients
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