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Documentos Principais

T0682

Sigma-Aldrich

Sodium taurohyodeoxycholate hydrate

≥98%

Sinônimo(s):

Taurohyodeoxycholic acid sodium salt hydrate

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About This Item

Fórmula linear:
C26H44NO6SNa · xH2O
Número CAS:
Peso molecular:
521.69 (anhydrous basis)
Número MDL:
Código UNSPSC:
12161900
ID de substância PubChem:
NACRES:
NA.25

descrição

anionic

Nível de qualidade

Ensaio

≥98%

peso molecular

521.69 g/mol (anhydrous basis)

aplicação(ões)

detection

cadeia de caracteres SMILES

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-7-24(30)27-12-13-34(31,32)33)19-5-6-20-18-15-23(29)22-14-17(28)8-10-26(22,3)21(18)9-11-25(19,20)2;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18+,19-,20+,21+,22+,23+,25-,26-;;/m1../s1

chave InChI

MJKUJELEPWZEGU-IGEKTTBWSA-M

Descrição geral

Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent.

Aplicação

Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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K J Van Erpecum et al.
European journal of clinical investigation, 26(7), 602-608 (1996-07-01)
Precipitation of cholesterol crystals is an essential step in gallstone formation. In the present study we found much faster and more extensive precipitation of various cholesterol crystal shapes in whole model biles containing the hydrophobic bile salt taurodeoxycholate than in
Francesca Carubbi et al.
Biochimica et biophysica acta, 1580(1), 31-39 (2002-03-30)
This study was performed to compare the effects of two hydrophilic bile acids, taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA), on HepG2 cells. Cytotoxicity was evaluated at different times of exposure by incubating cells with increasing concentrations (50-800 micromol/l) of
P Loria et al.
Hepatology (Baltimore, Md.), 25(6), 1306-1314 (1997-06-01)
This study aimed to determine the effect in humans of taurohyodeoxycholic acid, a 6alpha-hydroxylated bile acid with hydrophilic properties, on bile lipid secretion. Four cholecystectomized patients who had gallstones and an interrupted enterohepatic circulation were intraduodenally infused with taurohyodeoxycholic and
F Feletti et al.
Arzneimittel-Forschung, 43(8), 894-897 (1993-08-01)
The reproductive toxicity of taurohyodeoxycholic acid (3 alpha, 6 alpha-dihydroxy-5-beta-cholanoyl-2-amino-ethyl-sulfonic acid, THDCA, Io, Praxis, CAS 2958-04-5), a new synthetized biliary acid patented in Europe, Japan and the United States for prevention and therapy of gallstones and related symptoms, was assayed
M Paolini et al.
Hepatology (Baltimore, Md.), 30(3), 730-739 (1999-08-26)
We examined the effects of the administration of different bile acids on in vivo hepatic murine cytochrome P450 (CYP) content, nicotinamide adenine dinucleotide phosphate (NADPH)-CYP-reductase, and individual mixed-function oxidases (MFOs). Neither CYP level nor reductase were appreciably affected by single

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