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Merck
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Documentos Principais

580549

Millipore

Tauroursodeoxycholic Acid, Sodium Salt

Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.

Sinônimo(s):

Tauroursodeoxycholic Acid, Sodium Salt, Sodium Tauroursodeoxycholate

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About This Item

Fórmula empírica (Notação de Hill):
C26H44NO6S · Na
Número CAS:
35807-85-3
Peso molecular:
521.69
Número MDL:
MFCD31725069
Código UNSPSC:
12352106
NACRES:
NA.21

descrição

RTECS - KI7372500

Nível de qualidade

100

Ensaio

≥97% (TLC)

Formulário

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze

cor

white

solubilidade

water: 100 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

15-25°C

cadeia de caracteres SMILES

[S](=O)(=O)(O)CCNC(=O)CC[C@H]([C@@H]1[C@@]2(C(C3[C@H](C[C@H]4[C@@](C3CC2)(CC[C@H](C4)O)C)O)CC1)C)C

InChI

1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,22+,24?,25+,26-/m1/s1

chave InChI

BHTRKEVKTKCXOH-AYSJQVDDSA-N

Categorias relacionadas

Descrição geral

Detergent useful for the solubilization of lipids and membrane-bound proteins. Has cryoprotective effects against hydrophobic bile salts in rats. Also reported to inhibit pepsin activity in vitro.

Aplicação


  • Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats.: This study highlights the efficacy of tauroursodeoxycholic acid, sodium salt in reducing endoplasmic reticulum stress, suggesting its utility in preventing vascular complications in diabetes (Gaikwad AB et al., 2022).

Advertência

Toxicity: Standard Handling (A)

Outras notas

Ozcan, U., et al. 2006. Science313, 1137.
Miyake, H., et al. 1999. Dig. Dis. Sci.44, 197.
Eto, T. and Tompkins, R.K. 1985. Am. J. Surg.150, 564.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Taurodeoxycholic Acid, Sodium Salt Detergent useful for the solubilization of lipids and membrane-bound proteins. Aggregation number: 6.

Millipore

580221

Taurodeoxycholic Acid, Sodium Salt

Salubrinal ≥98% (HPLC)

Sigma-Aldrich

SML0951

Salubrinal

Sodium phenylbutyrate European Pharmacopoeia (EP) Reference Standard

Y0000808

Sodium phenylbutyrate

Sodium taurolithocholate

Sigma-Aldrich

T7515

Sodium taurolithocholate

Taurodesoxicolato de sódio BioXtra, ≥97% (TLC)

Sigma-Aldrich

T0557

Taurodesoxicolato de sódio

Tunicamycin, Streptomyces lysosuperficus

Sigma-Aldrich

654380

Tunicamycin, Streptomyces lysosuperficus

Hyodeoxycholic acid ≥98%

Sigma-Aldrich

H3878

Hyodeoxycholic acid

Crystal L Kraft et al.
Oncotarget, 8(61), 102923-102933 (2017-12-22)
Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium. Their long life, lineage plasticity, and proliferative potential underlie the necessity for tight homeostatic regulation of
Yaqin Chen et al.
PloS one, 8(10), e81379-e81379 (2013-11-28)
Adipocytes behave as a rich source of adipokines, which may be the link between obesity and its complications. Endoplasmic reticulum (ER) stress in adipocytes can modulate adipokines secretion. The aim of this study is to evaluate the effect of oxidized
Xiaoling Li et al.
The Journal of biological chemistry, 293(14), 5160-5171 (2018-02-25)
The liver is a major organ in lipid metabolism, and its malfunction leads to various diseases. Nonalcoholic fatty liver disease, the most common chronic liver disorder in developed countries, is characterized by the abnormal retention of excess lipid within hepatocytes
Emily M Nakada et al.
JCI insight, 4(9) (2019-05-03)
Conjugated bile acids (CBAs), such as tauroursodeoxycholic acid (TUDCA), are known to resolve the inflammatory and unfolded protein response (UPR) in inflammatory diseases, such as asthma. Whether CBAs exert their beneficial effects on allergic airway responses via 1 arm or
Isabel Castro et al.
Rheumatology (Oxford, England), 59(4), 742-753 (2019-08-05)
Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin
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