SRP3050
Granulocyte-Macrophage Colony-Stimulating Factor human
GM-CSF, Animal-component free, recombinant, expressed in E. coli, suitable for cell culture
Sinônimo(s):
CSF-2, MGI-1GM, pluripoietin-a
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in E. coli
Ensaio
≥98% (SDS-PAGE)
Formulário
lyophilized
potência
≤0.1 ng/mL
peso molecular
14.6 kDa
embalagem
pkg of 20 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
técnica(s)
cell culture | mammalian: suitable
Impurezas
≤1 EU/μg endotoxin, tested
cor
white to off-white
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... CSF2(1437)
Descrição geral
GM-CSF (granulocyte-macrophage colony-stimulating factor, also referred to as CSF2) is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. Recombinant human GM-CSF is a 14.6kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. The human and murine molecules are species-specific and exhibit no cross-species reactivity.
Aplicação
Granulocyte-Macrophage Colony-Stimulating Factor human has been used in the medium for plating of the cells. It has been used in culture medium for the differentiation of human peripheral blood mononuclear cells.
Ações bioquímicas/fisiológicas
GM-CSF (granulocyte-macrophage colony-stimulating factor, also referred to as CSF2) is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It enhances neutrophil migration and enhances the functional activity of the mature end-cells.
Sequência
MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE
forma física
Lyophilized from 10 mM Sodium Citrate, pH 3.5.
Reconstituição
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Candida parapsilosis produces prostaglandins from exogenous arachidonic acid and OLE2 is not required for their synthesis.
Grozer Z, et al.
Virulence, 6, 85-92 (2015)
Siddappa N Byrareddy et al.
PloS one, 10(10), e0140689-e0140689 (2015-10-16)
Lectin-like molecules and their receptors are cell surface molecules that have been shown to play a role in either facilitating infection or serving as transporters of HIV/SIV in vivo. The role of these lectin-like molecules in the pathogenesis of HIV/SIV
Rapamycin inhibits GM-CSF-induced neutrophil migration.
Gomez-Cambronero J
Febs Letters, 550, 94-100 (2003)
Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD.
He JQ
The European Respiratory Journal, 32, 25-34 (2008)
Growth of clonogenic myeloblastic leukemic cells in the presence of human recombinant erythropoietin in addition to various human recombinant hematopoietic growth factors.
Asano Y
Blood, 72, 1682-1686 (1988)
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